Potential Ameliorative Effects of Kampo Medicines Ninjin’yoeito and Kamikihito on Frailty-Like Behavior in Naturally Aged C57BL/6J Mice

Frailty is defined as an age-related decline in physiological reserve and increased vulnerability to stress. As frailty a multifaceted condition, there no effective pharmacotherapy for it yet. Ninjin’yoeito (NYT) Kamikihito (KKT), traditional Japanese medicines (Kampo medicines), are promising treating conditions of including fatigue mental anxiety. However, their effects still unclear. In this study, the NYT KKT on different types naturally aged mice were explored by survival, physical aspects (Frailty Assessment Scores muscle strength measurements), psychological (sucrose splash test motivation-related behavior), social (rescue-like behavior prosocial behavior). Mice 22-months fed diet containing 3% or 3%KKT 13 weeks until age 25 months. Behavioral alterations old compared with those adult (five months old). Throughout study period, Old-control showed frailty-like symptoms, elevation assessment score, reduction motivation self-care, rescue-like mice. survival rate suppressed declines strength, self-care. reduced decreases These results suggest that alleviate general symptoms Additionally, may extend lifespan. findings be helpful improving frailty.